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Track small thyroid nodules with regular ultrasound over five years | stella

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Watching small thyroid lumps without surgery for five years

Plain-English translation of NCT07370675 on ClinicalTrials.gov ↗ · Source last updated January 2026 · Translation generated June 2026 · How we translate trials

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This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.

What is this trial?

This study is testing whether watching small thyroid nodules closely — using ultrasound scans and clinical check-ups — is a safe choice instead of having surgery right away. Right now, many people with small, uncertain thyroid lumps get operated on even though most turn out to be harmless. Researchers want to see if careful monitoring over five years can avoid unnecessary surgery while keeping patients safe.

Surgery for small thyroid nodules often causes side effects like lifelong need for thyroid medication, voice problems, and nerve damage — and most of the time the nodule wasn't cancer anyway. This study exists to prove that watching these nodules closely is just as safe and spares people from surgery they may not need.

Do you qualify?

You likely qualify if…

you are 30 years old or older
you have a single small thyroid nodule (less than 2 cm) with uncertain cells that need further study
your recent ultrasound shows the nodule is low to intermediate risk (EU-TIRADS 3 or 4)
you have not had thyroid surgery before
you are willing to return for regular ultrasound scans and check-ups over five years

You likely don't qualify if…

your ultrasound shows the nodule is high-risk (EU-TIRADS 5)
there are signs the nodule may have spread to lymph nodes or beyond the thyroid
the nodule is pressing on blood vessels, your voice nerve, or windpipe
you are pregnant or unable to give informed consent
you have an elevated calcitonin level or untreated high calcium and parathyroid hormone levels

What participation looks like

You would visit the clinic regularly over five years for ultrasound scans and physical exams to monitor your nodule. Between visits, you would track any changes in symptoms and report them to the research team. The study aims to show whether most small, uncertain nodules stay stable without surgery, allowing you to avoid an operation and its side effects while staying safe.

AI-generated summary from trial data · Jun 7, 2026 · Not medical advice

Trial locations(1 site)

Denmark

Department of Otolaryngology, Head and Neck SurgeryRigshospitalet, Copenhagen

Key details

Sponsor

Christian Grønhøj Larsen

Collaborators

Copenhagen University Hospital, Rigshospitalet

Enrollment target

~165 participants

Started

January 2026

Primary completion

January 2033

Age range

30 Years and older

Last updated on clinicaltrials.gov in January 2026.

Contact the research team directly

Reach out to the team running this trial. Response times vary — some teams are faster than others.

Central contact

Nicoline Thorup, MD, PhD Fellow

Christian Grønhøj Larsen

Interested in joining?

Tell us you're interested and we'll help connect you with the research team. We'll walk you through what to expect first — no email needed to get started.

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View full record on ClinicalTrials.gov