Plain-English translation of NCT07371273 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Read our Colorectal Cancer research guide →Phase 2 — Testing in a bigger group (up to a few hundred people) to see if the treatment actually works and is still safe.
This trial is testing three different surgical techniques for treating rectal cancer that occurs very close to the anus. Researchers want to see whether a newer, more targeted approach called Q-ISR—which removes only the parts of the sphincter muscle affected by cancer and spares the healthy parts—works as well as traditional surgery for removing cancer while better preserving your ability to control bowel function.
Traditional surgery for very low rectal cancer often removes the entire internal sphincter muscle, which can lead to long-term problems with bowel control and quality of life. This trial exists to see whether a more selective surgical approach can protect the healthy muscle while still achieving complete cancer removal.
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You will undergo one of the three surgical approaches to remove your rectal cancer while attempting to preserve sphincter function. After surgery, you will be monitored for short-term safety outcomes such as complications and recovery. You will also be assessed in the long term for bowel function (through questionnaires measuring continence and quality of life) and cancer outcomes (checking for recurrence and survival). The study will track you over both short and long periods to compare how well each surgical technique works.
AI-generated summary from trial data · Jun 6, 2026 · Not medical advice
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