Plain-English translation of NCT07373782 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Phase 3 — Testing in thousands of people, comparing the treatment against what doctors currently use. This is the last big step before approval.
This trial is testing whether adding continuous positive airway pressure (CPAP)—a breathing assistance device—during radiation therapy for breast cancer can reduce the amount of radiation exposure to the heart. Women who have had breast-conserving surgery for early-stage breast cancer are invited to participate. The study compares standard radiation treatment with and without CPAP to see if this simple addition can protect your heart while treating cancer effectively.
Radiation therapy for breast cancer, especially on the left side, can expose the heart to radiation that may increase heart disease risk later in life. This trial exists to see whether using a breathing device during treatment can position your organs in a way that keeps radiation away from your heart, reducing long-term harm without compromising cancer treatment.
You likely qualify if…
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You will have an extra CT scan (imaging test) while wearing a CPAP breathing device to help doctors plan your treatment. Doctors will create two radiation treatment plans—one with CPAP and one without—and compare them to see if CPAP reduces radiation to your heart. If CPAP reduces heart exposure significantly, you will receive your radiation therapy while using the device during free breathing (right-sided) or deep breath-holding (left-sided). You will also complete surveys about your comfort with the breathing device.
AI-generated summary from trial data · Jun 27, 2026 · Not medical advice
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