Collagen injections combined with hormone therapy for early endometrial cancer

Plain-English translation of NCT07377734 on ClinicalTrials.gov ↗ · Source last updated March 2026 · Translation generated June 2026 · How we translate trials

Phase 2 — Testing in a bigger group (up to a few hundred people) to see if the treatment actually works and is still safe.

What is this trial?

This trial is testing a new approach to treating early endometrial cancer and precancerous endometrial changes in young people who want to have children. Researchers are studying whether Recombinant Humanized Type III Collagen Lyophilized Fibers, injected directly into the uterus, can work better when combined with hormone therapy (progestin pills) compared to hormone therapy alone. The goal is to find a treatment that destroys or shrinks the cancer or precancerous tissue while keeping your uterus intact and your fertility options open.

Standard treatment for endometrial cancer usually means removing the uterus, which ends the ability to have biological children. This medication is being studied to see if it could offer young patients another option—one that treats the cancer effectively while preserving fertility.

Do you qualify?

You likely qualify if…

you are 45 years old or younger
you have been diagnosed with early-stage endometrial cancer (Stage IA only, with cancer confined to the inner lining or minimally invading the muscle layer) or atypical endometrial hyperplasia (a precancerous condition)
you strongly want to preserve your ability to have children and are willing to participate
you have no serious liver or kidney disease
you have no distant spread of cancer on imaging
you have no contraindications to progestin therapy or pregnancy

You likely don't qualify if…

you have cancer that has invaded more than half the muscle layer of the uterus, or advanced-stage disease (Stage IB or higher)
you have poorly differentiated cancer or non-endometrioid types of endometrial cancer
you have a known allergy to recombinant proteins
you have an active genital tract infection or untreated abnormal vaginal discharge within the past 2 weeks
you have received high-dose progestin therapy for more than one month already

What participation looks like

You will take pills by mouth every day. If you are randomly assigned to the experimental group, you will also receive three intrauterine collagen injections—one at the start, one at 1 month, and one at 2 months—each given through a minimally invasive procedure called hysteroscopy. Every 3 months, you will visit the clinic for follow-up appointments that include a small biopsy of the uterine lining, ultrasound imaging, and blood tests to monitor your response and safety.

AI-generated summary from trial data · Jun 10, 2026 · Not medical advice

Collagen injections combined with hormone therapy for early endometrial cancer

What is this trial?

Do you qualify?

What participation looks like

Trial locations(1 site)