Cord Blood Transplant for EBV-Related Blood Cell Disorders

Plain-English translation of NCT07381738 on ClinicalTrials.gov ↗ · Source last updated February 2026 · Translation generated July 2026 · How we translate trials

Phase 2 — Testing in a bigger group (up to a few hundred people) to see if the treatment actually works and is still safe.

What is this trial?

This trial is testing unrelated cord blood transplantation as a treatment for serious disorders caused by Epstein-Barr virus (EBV), a common virus that can sometimes cause life-threatening immune system problems. In this procedure, healthy blood-forming cells from donated umbilical cord blood are infused into your body to help rebuild your immune system and fight the EBV infection. Researchers want to see if this treatment can help patients who haven't responded well to other therapies.

EBV-related disorders can be extremely serious, especially in people from East Asia, and current treatments don't work for everyone. This trial exists because transplantation is believed to be the most promising way to cure these conditions, but doctors need to learn more about using cord blood specifically as the source of donor cells.

Do you qualify?

You likely qualify if…

you are between 14 and 80 years old
you have been diagnosed with a chronic active EBV infection, EBV-related blood cell disease, or EBV-associated lymphoma confirmed by a doctor
you have had ongoing symptoms (such as fever or enlarged organs) for more than 3 months and have high levels of EBV virus in your blood or tissues
you are in reasonably good overall health (able to perform light activities and expected to live at least 3 more months)
you are willing to sign an informed consent form (parents or guardians sign for minors)

You likely don't qualify if…

you have had another type of cancer in the past 5 years
you have active hepatitis B, hepatitis C, or HIV infection
you have severe heart disease or serious uncontrolled infections
you are pregnant, breastfeeding, or planning to become pregnant
you have a history of severe mental illness or substance abuse

What participation looks like

If you qualify, you will receive a standard-dose transplant of cord blood cells at one of two medical centers in China. Before the transplant, you will likely undergo preparation treatment to make room for the new cells. After the transplant, you will be closely monitored for how well the new cells take hold and whether your EBV symptoms improve. The trial will track your health and recovery over time to evaluate whether this treatment is safe and effective for you.

AI-generated summary from trial data · Jul 6, 2026 · Not medical advice

Trial locations(2 sites)

China

Huadong hospital, Fudan university, Shanghai, Shanghai Municipality

Huashan Hospital, Fudan University, Shanghai, Shanghai Municipality