How kidney function affects a diabetes medication

Plain-English translation of NCT07385547 on ClinicalTrials.gov ↗ · Source last updated March 2026 · Translation generated June 2026 · How we translate trials

Phase 1 — Testing in a small group (usually 20–80 people) to find a safe dose and watch for side effects.

What is this trial?

This is an early-stage study testing a new diabetes medication called , which is designed to help control blood sugar over a long period. Researchers want to understand how kidney function affects the way this medication moves through your body, so they can make sure it's safe and effective for people with kidney disease.

Many people with diabetes also have kidney problems, but we don't yet know whether this medication needs to be given in different doses for those patients. This study will help doctors decide how to safely use this treatment for people with compromised kidney function.

Do you qualify?

You likely qualify if…

you are between 18 and 80 years old
you have a body mass index between 18 and 42
you have one of four specific kidney function levels (normal, moderate impairment, severe impairment, or severe impairment requiring dialysis)
you are willing to use effective birth control for 4 weeks before and 30 days after receiving the medication
you have had stable kidney function for at least 3 months and are otherwise in good health

You likely don't qualify if…

you have a high calcitonin level (≥50 ng/L), which could indicate other health issues
you are currently on continuous kidney replacement therapy or peritoneal dialysis
your blood pressure or heart rate are outside safe ranges at screening

What participation looks like

You will come to the study center for screening visits to confirm your kidney function and overall health. If you qualify, you will receive a single injection of the medication under your skin. After that, you'll have blood tests collected at several timepoints to measure how the medication moves through your body and how well you tolerate it.

AI-generated summary from trial data · Jun 16, 2026 · Not medical advice

Trial locations(3 sites)

United States

Syneos Miami, Miami, Florida

Panax Clinical Research, Miami Lakes, Florida

Orlando Clinical Research Center (OCRC), Orlando, Florida