How gut bacteria and diet affect babies born to parents with inflammatory bowel disease

Plain-English translation of NCT07385807 on ClinicalTrials.gov ↗ · Source last updated April 2026 · Translation generated June 2026 · How we translate trials

What is this trial?

This study is exploring how a parent's gut bacteria and what they eat during pregnancy might affect their baby's digestive health and future risk of conditions like asthma, eczema, or inflammatory bowel disease. Researchers will compare pregnant people who have inflammatory bowel disease with those who don't, collecting stool samples and dietary information over one year to understand these connections better.

Babies born to parents with inflammatory bowel disease often show signs of digestive inflammation that may increase their risk of developing similar conditions later in life. This study aims to find out whether changes to diet during pregnancy could help protect these infants' digestive health.

Do you qualify?

You likely qualify if…

you are pregnant and at least 19 years old, recruited during your first, second, or early third trimester
you own or have regular access to a smartphone that can use the study's food tracking app
you have been diagnosed with inflammatory bowel disease (Crohn's disease or ulcerative colitis) with either active or inactive disease, OR you do not have inflammatory bowel disease

You likely don't qualify if…

you have a history of bowel cancer or previous bowel surgery
you are currently taking probiotic, prebiotic, or postbiotic supplements in the month before starting the study
you have kidney disease, HIV/AIDS, or other serious infections
you had gastroenteritis (stomach flu) during or one month before your first sample collection
you traveled outside Canada or the United States in the month before your first sample collection

What participation looks like

You would provide stool samples, vaginal swabs, and optional breastmilk samples using an at-home kit delivered to your home at four timepoints: during your third trimester of pregnancy, two weeks after birth, three months after birth, and one year after birth. You would also track what you eat for three days before each collection and answer questions about your health and your baby's health. The entire study lasts about one year.

AI-generated summary from trial data · Jun 14, 2026 · Not medical advice

How gut bacteria and diet affect babies born to parents with inflammatory bowel disease

What is this trial?

Do you qualify?

What participation looks like

Trial locations