Plain-English translation of NCT07386600 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
This trial is testing whether adding one of two medications—dexamethasone or —to nerve blocks during knee replacement surgery can reduce pain better than using the nerve block alone. Nerve blocks are injections that numb specific nerves around the knee to relieve pain after surgery. The study wants to find out which additive medication works best and is safest for older adults having knee replacement.
Knee replacement surgery causes significant pain after the operation, which can make recovery harder and increase the need for strong opioid painkillers. Nerve blocks help, but their pain relief doesn't last very long, so doctors are looking for ways to make them work longer and better.
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If you join this trial, you will receive knee replacement surgery with standard anesthesia. During surgery, you will receive nerve blocks—numbing injections around your knee—with one of the study treatments: the standard numbing medication alone, the numbing medication plus dexamethasone, or the numbing medication plus . You will then be monitored for pain relief and any side effects during your hospital stay and recovery. The study team will track your pain levels and how much pain medication you need after surgery.
AI-generated summary from trial data · Jun 12, 2026 · Not medical advice
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