Plain-English translation of NCT07387796 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
Researchers want to understand what happens in your body and brain when you stop and restart tirzepatide, a weight loss medication you're already taking. This trial will carefully monitor you during a brief pause from the medication and then when you start it again, using brain imaging and health questionnaires to track any changes.
When people stop taking weight loss medications, doctors don't fully understand how the brain and body adjust or what side effects might occur. This research aims to fill that gap so doctors can better support patients who pause or restart this treatment.
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You'll attend three in-person visits: one while taking the medication normally, one during a 3–4 week pause, and one after restarting for 6–8 weeks. At each visit, you'll complete interviews, questionnaires, cognitive tasks, a brain MRI scan, and provide stool samples. Between visits, you'll have two brief phone check-ins and complete an online brain health assessment. A study doctor will oversee all medication changes to keep you safe.
AI-generated summary from trial data · Sep 17, 2026 · Not medical advice
United States