Plain-English translation of NCT07393048 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
This research study is testing a new way to use blood tests to predict whether cancer treatment will work well for people with locally advanced rectal cancer. Researchers will collect blood and tissue samples from you at different points during your cancer treatment to look for tiny pieces of cancer DNA circulating in your blood. The goal is to create a tool that can help doctors know early on whether your treatment is working, so they can adjust your care if needed.
Currently, doctors have to wait until surgery to see whether cancer treatment worked. This new blood test approach could tell doctors much earlier—while you're still receiving treatment—whether the medication is effective. This could help doctors personalize your care and potentially improve your outcomes.
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You will have blood samples taken at three key times: before you start treatment, about 2 weeks after radiation therapy is complete, and after surgery. A small tissue sample will also be collected before treatment begins. Each blood draw is only about 10 milliliters (roughly 2 teaspoons). The study team will analyze your blood and tissue to look for cancer DNA patterns and track how your tumor responds to treatment. This is an observational study, meaning you'll receive your standard cancer treatment as planned—the study is simply tracking your progress with these special blood tests.
AI-generated summary from trial data · Aug 14, 2026 · Not medical advice
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