Plain-English translation of NCT07395960 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Phase 1/2 — A combined trial that checks safety and dosing while also starting to look at whether the treatment works.
This research trial is testing metformin, a medication commonly used to treat diabetes, to see if it can help improve memory and thinking abilities in older adults who are overweight or have obesity and are experiencing mild cognitive impairment (early memory and thinking problems). The study will compare people who take this medication with people who receive a placebo (inactive pill) to see if the medication makes a real difference in brain function and cognitive health.
Many older adults who are overweight or obese experience early memory and thinking problems, and these issues can sometimes progress to more serious cognitive decline. Researchers believe this medication may help by improving how the brain uses insulin, which plays an important role in memory and learning, making it worth testing as an early intervention.
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If you join this study, you will be randomly assigned to either take metformin (a daily pill at 1,500 mg) or a placebo (inactive pill) for a period of time. You will visit the research center for evaluations that include cognitive testing and brain imaging (MRI scans) to measure any changes in your memory and thinking. The researchers will also monitor your health and any side effects throughout the study.
AI-generated summary from trial data · Jun 8, 2026 · Not medical advice
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