Plain-English translation of NCT07397611 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Phase 2 — Testing in a bigger group (up to a few hundred people) to see if the treatment actually works and is still safe.
This is a research study testing two experimental medications— and —for people with clear cell renal cell carcinoma (a common type of kidney cancer) who are planning to have surgery. Half of participants will take alone, and half will take combined with . The goal is to see whether these medications are safe and whether they help shrink tumors or improve outcomes before and after surgery.
Currently, these medications are not FDA-approved for kidney cancer treatment. Doctors want to know whether giving these drugs before surgery—rather than after—might help patients with more advanced kidney tumors have better outcomes.
You likely qualify if…
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You will have a baseline visit with screening tests (blood work, imaging scans, and heart function checks). Then you'll take the medication by mouth once daily for three 21-day cycles before your planned kidney surgery. If you're in the combination group, you'll also receive the second medication by injection on the first day of each cycle. After surgery, you'll have follow-up appointments and scans for up to 3 years to monitor how you're doing.
AI-generated summary from trial data · Jun 7, 2026 · Not medical advice
United States