Plain-English translation of NCT07397728 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Researchers want to understand why some people with lupus develop skin problems and others don't. This study focuses on a gene called TREX1, which may play a role in lupus by allowing damaged DNA to build up inside cells and trigger the immune system. By comparing genetic information from people with lupus (especially those with skin involvement) to healthy people, the research team hopes to discover patterns that explain disease severity and how skin symptoms develop.
Lupus affects the skin in over 70% of patients, but doctors don't fully understand why some people have worse skin involvement than others or how to predict flare-ups. Understanding the genetic basis of these skin symptoms could help with early diagnosis, predict when flares might happen, and lead to more personalized treatment plans tailored to each patient's genetic profile.
You likely qualify if…
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If you join, you would be part of either the lupus patient group (60 people with skin symptoms) or the healthy control group (30 people without lupus). Your main involvement would be donating a blood sample, which researchers will test for genetic information and antibodies related to lupus. The study is observational, meaning you won't receive a new treatment—researchers are simply studying your genes and disease patterns to understand lupus better.
AI-generated summary from trial data · Jun 2, 2026 · Not medical advice
Egypt
Sponsor
South Valley University
Enrollment target
~90 participants
Started
June 2025
Primary completion
June 2026
This trial's estimated completion date has passed — the record may not be fully up to date.
Age range
18 Years – 60 Years
Last updated on clinicaltrials.gov in February 2026.
Reach out to the team running this trial. Response times vary — some teams are faster than others.
Central contact
Amira Rabea AbuElfadl, MSc
Dermatology, Venereology and Andrology. Faculty of Medicine,Qena University
Tell us you're interested and we'll help connect you with the research team. We'll walk you through what to expect first — no email needed to get started.