Plain-English translation of NCT07397845 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Read our Coronary Artery Disease research guide →This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
This trial is testing whether two newer catheter-based approaches work as well as—or better than—the standard treatment for opening blocked heart arteries. One approach uses a special balloon coated with paclitaxel (a medication that prevents the artery from narrowing again) without leaving a permanent stent behind. The other uses a different coated balloon device. Both are compared to the traditional approach of placing a drug-coated stent (a small metal tube) permanently in the artery.
Even with modern stents, some patients experience the artery narrowing again over time. Doctors are exploring whether using coated balloons alone—without implanting a permanent device—might reduce this problem and lower the risk of blood clots, especially in patients with complex or small coronary arteries.
You likely qualify if…
You likely don't qualify if…
If you qualify, you will first have your artery blockage prepared using a standard technique, and then you will be randomly assigned to receive one of the three treatments during your catheterization procedure. You will be monitored during the procedure and will have follow-up appointments to check how well the treatment is working and to watch for any complications over time. The study will track your health outcomes for at least 2 years after the procedure.
AI-generated summary from trial data · Aug 9, 2026 · Not medical advice
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