Plain-English translation of NCT07401277 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Phase 1 — Testing in a small group (usually 20–80 people) to find a safe dose and watch for side effects.
This trial is testing whether 5-fluorouracil cream—a medication already used to treat sun-damaged skin spots—works even better when combined with aluminum chloride hexahydrate, a substance that may help the cream penetrate the skin more effectively. These rough, scaly spots, called actinic keratoses, are common in older adults and can sometimes turn into skin cancer if left untreated. The study compares the new combination to the standard treatment alone to see which one reduces these spots more effectively.
Doctors want to find better ways to treat areas with many sun-damaged spots. This medication may help remove these spots, but researchers believe adding another ingredient could make it work even better at clearing them.
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You will apply a cream to half of the affected area (either your scalp or forearms) for one week. One half will receive the standard treatment and the other half will receive the new combination—you won't know which is which. A dermatologist will examine your skin and take photographs before treatment starts, shortly after the week ends, and again about eight weeks later to count how many spots remain and compare the results.
AI-generated summary from trial data · Aug 26, 2026 · Not medical advice
United States