Plain-English translation of NCT07401381 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Phase 1 — Testing in a small group (usually 20–80 people) to find a safe dose and watch for side effects.
This study is testing a new way to deliver letrozole, a hormone therapy medication for breast cancer. Instead of taking a daily pill, you would receive a quarterly injection. The researchers want to understand whether this new injection form delivers the same amount of medication into your body as the daily pills you may already be familiar with.
Women with hormone-receptor-positive breast cancer often need to take hormone therapy for many years, which means taking a daily pill. This trial exists to see if a quarterly injection could work just as well, potentially making treatment easier by reducing how often you need to remember to take medication.
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You would start by taking daily oral letrozole pills for 14 days to reach steady levels in your body. Then you would switch to receiving quarterly injections of the new medication while doctors monitor how much medication is in your bloodstream. Some participants may also continue into an extension phase to see how your body eliminates the medication over time. The study includes screening visits, multiple treatment periods, and blood draws to measure medication levels.
AI-generated summary from trial data · Aug 8, 2026 · Not medical advice
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