Plain-English translation of NCT07403604 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Phase 1 — Testing in a small group (usually 20–80 people) to find a safe dose and watch for side effects.
This trial is testing whether a medication called diazoxide can help reduce the buildup of fat in the liver. Researchers believe that high insulin levels may drive excessive fat production in the liver, especially in people with insulin resistance. This study will see if lowering insulin with this medication can reduce that harmful fat buildup.
Many people with obesity and prediabetes develop unhealthy fat accumulation in their liver, but doctors don't fully understand why high insulin levels make this worse. This study could help identify a new way to treat this condition by lowering insulin rather than managing blood sugar alone.
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You would participate in two separate one-week study periods, spaced 4 to 12 weeks apart. During each week, you'll take a liquid medication (or placebo) twice daily for 7 days, drink special labeled water daily to help researchers measure fat production in your liver, and come in for fasting blood draws and saliva collections at the beginning and end of each period. Most participants will receive placebo during the first week and then the actual medication during the second week.
AI-generated summary from trial data · Jul 14, 2026 · Not medical advice
United States