Plain-English translation of NCT07404085 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
This trial is testing whether a combination of virtual reality brain training and a daily supplement called sodium butyrate can help improve thinking and memory problems in middle-aged and older adults who have depression or bipolar disorder. Some participants will receive brain training with the medication, some will receive brain training with a placebo (a pill with no active ingredient), and some will receive brain training with less intensity combined with the medication. The study will measure how well people think and remember, and how their brain activity changes.
Many people with depression or bipolar disorder struggle with thinking, memory, and focus even when their mood symptoms are well-managed. This trial is testing whether this medication might boost the benefits of brain training to help improve these cognitive problems.
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You will start with two baseline assessment days, which include thinking tests, brain imaging scans, questionnaires about your mood and quality of life, and some memory tasks. Then you'll be randomly assigned to one of four groups: some will do intensive virtual reality brain training with the supplement, some with a placebo, and some will do lighter brain training with the supplement. The brain training program lasts three weeks and involves weekly sessions with a therapist plus homework tasks. You'll have follow-up assessments after the program ends to see how much your thinking skills have improved.
AI-generated summary from trial data · Jun 2, 2026 · Not medical advice
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