A minimally invasive treatment for a specific type of aortic tear

Plain-English translation of NCT07405242 on ClinicalTrials.gov ↗ · Source last updated February 2026 · Translation generated August 2026 · How we translate trials

This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.

What is this trial?

This trial is testing a minimally invasive procedure called endovascular treatment with stent implantation for patients with a specific type of aortic dissection (a tear in the aorta). The procedure is designed for patients whose aortic tear starts in the lower part of the aorta and extends backward into the upper part near the heart, and who cannot safely have traditional open-heart surgery. Doctors will insert a special tube-like device (stent) through blood vessels to repair the tear from the inside.

Some patients with this type of aortic dissection are too sick or at too high a risk to undergo traditional open-heart surgery. This trial exists to see whether a less invasive stent-based approach can safely treat these patients and help them recover better than surgery might.

Do you qualify?

You likely qualify if…

you are 65 years of age or older
you have been diagnosed with a retrograde aortic dissection confirmed by imaging, where the tear is in the aortic arch or lower aorta and extends backward into the ascending aorta
you have been evaluated by a heart surgeon and determined to be unsuitable for open-heart surgery due to high surgical risk
the tear in your aorta is at least 2 centimeters away from where the coronary arteries branch off from the heart
your blood vessels are large and healthy enough to allow the stent delivery system to pass through without blockage or severe narrowing

You likely don't qualify if…

you have severe organ damage or failure (such as major stroke, severe kidney failure, or extensive bowel damage) that cannot be helped by this procedure
you have a severe allergy to contrast dye or stent materials like nickel-titanium
you have a severe leaking aortic valve or a mechanical heart valve
you have a severe bleeding disorder or active severe infection
you are pregnant or breastfeeding, or you have another serious illness expected to shorten your life to less than one year

What participation looks like

If you qualify, you will undergo the endovascular stent procedure during a hospital visit, where doctors will insert the stent through your blood vessels to repair the aortic tear. After the procedure, you will be followed up with medical visits and imaging tests at 30 days, 6 months, and 12 months to monitor your recovery, check for complications, and see how well the stent is working. The entire study lasts about one year from the time of your procedure.

A minimally invasive treatment for a specific type of aortic tear

What is this trial?

Do you qualify?

What participation looks like

Trial locations(1 site)