Plain-English translation of NCT07405645 on ClinicalTrials.gov โ ยท Source last updated ยท Translation generated ยท How we translate trials
This study doesn't follow the usual testing phases โ it may be an observational study or a different type of research.
This trial is testing a procedure called stereotactic MRI-guided focused ultrasound mesencephalotomy to treat severe cancer pain in the head, neck, and arm areas. The procedure uses focused ultrasound waves guided by MRI imaging to create a small, precise lesion in a part of the brain that processes pain signals. This treatment is being studied for people whose pain has not improved with standard cancer medications, including strong opioids.
Cancer pain in the head, neck, and arm regions is notoriously difficult to treat with medications alone and is not suitable for traditional surgical pain-relief options. This new ultrasound technique offers a less invasive alternative that uses advanced imaging to target pain pathways in the brain with extreme precision.
You likely qualify ifโฆ
You likely don't qualify ifโฆ
If you qualify, you would undergo a single focused ultrasound procedure guided by MRI imaging to treat your pain. Before the procedure, you'll have detailed MRI scans to plan the exact treatment location. During the procedure, you'll communicate with the medical team about your sensations so they can monitor the treatment in real time. After the procedure, you'll be monitored and asked to report your pain levels using standard pain rating scales during follow-up visits.
AI-generated summary from trial data ยท Jun 16, 2026 ยท Not medical advice
United States