Recruiting

Testing a new medication to slow kidney disease progression

Plain-English translation of NCT07419828 on ClinicalTrials.gov ↗ · Source last updated March 2026 · Translation generated June 2026 · How we translate trials

Phase 3 — Testing in thousands of people, comparing the treatment against what doctors currently use. This is the last big step before approval.

What is this trial?

This is a large research study testing whether a new medication called HRS-1780 can help protect your kidneys and slow down kidney disease progression. You would either receive the new medication or a placebo (a pill with no active ingredient) alongside your regular kidney disease treatment. The study will track your kidney function over time to see if the medication makes a difference.

Chronic kidney disease can gradually worsen over time, even with standard treatment. Researchers are testing this medication to see if it can help slow that decline and give people with kidney disease more treatment options.

Do you qualify?

You likely qualify if…

you are between 18 and 79 years old
you have been diagnosed with chronic kidney disease with specific levels of kidney function and protein in your urine (your doctor can tell you if you qualify based on your recent blood and urine tests)
your potassium levels are controlled (at or below 4.8 mmol/L)
your blood sugar control is reasonably managed (HbA1c less than 10.5%)

You likely don't qualify if…

you have very high blood pressure that is not well controlled, or very low blood pressure
you have had acute kidney injury or needed dialysis in the past 3 months
you have received a kidney transplant or are planning one during the study
you have had a recent stroke, heart attack, or serious heart condition within the past 3 months
you have certain other serious medical conditions (like polycystic kidney disease or specific immune disorders) that doctors believe would interfere with the study

What participation looks like

If you join this study, you will be randomly assigned to take either HRS-1780 or a placebo pill as part of your regular kidney disease care. You will need to visit the research center for regular check-ups where your kidney function will be monitored through blood and urine tests. The study involves nearly 2,000 participants, and you would be followed over time to see how the medication affects your kidney function compared to placebo.

AI-generated summary from trial data · Jun 18, 2026 · Not medical advice

Trial locations(1 site)

China

National Clinical Research Center of Kidney Diseases, Jinling Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, Jiangsu