Plain-English translation of NCT07420543 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
This is a research study for patients with brain tumors who are having surgery with a special fluorescent dye called 5-ALA to help surgeons see the tumor more clearly. The study wants to understand whether measuring certain markers in your blood, serum, and urine before and after the dye is given can help doctors better understand your tumor and improve treatment in the future.
Doctors need better ways to understand brain tumors and predict how they will respond to treatment. This research aims to see if simple blood and urine tests can provide useful information about your tumor that isn't available from imaging alone.
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You will have samples of blood, serum, and urine collected at two timepoints: once before you receive the fluorescent dye (5-ALA) and again 12 hours after you receive it. You will also have a routine MRI scan before surgery as part of your normal care. The samples will be analyzed to measure fluorescent markers, and the results will be compared to your tumor size to see if there are useful patterns.
AI-generated summary from trial data · Jun 4, 2026 · Not medical advice
Italy
Sponsor
Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta
Collaborators
University of Milan, Università degli Studi del Piemonte Orientale Amedeo Avogadro
Enrollment target
~30 participants
Started
January 2017
Primary completion
May 2026
This trial's estimated completion date has passed — the record may not be fully up to date.
Age range
18 Years and older
Last updated on clinicaltrials.gov in February 2026.
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Central contact
Francesco Di Meco, MD
Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta
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