Plain-English translation of NCT07420543 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
This research study is testing whether simple blood and urine samples can help doctors better understand brain tumors during surgery. If you have a brain tumor and are planning to have surgery, doctors will collect samples from you before and after you receive a medication called 5-ALA (which helps surgeons see tumors more clearly during the operation). The study will measure special chemicals in your blood and urine to see if they match what surgeons find in the tumor itself.
Currently, doctors rely mainly on imaging scans and what they see during surgery to understand brain tumors. This medication could offer a simpler, less invasive way to detect tumor markers through blood and urine, potentially helping doctors catch tumors earlier or monitor them better over time.
You will have blood, serum, and urine collected at two timepoints: once before you receive the 5-ALA medication and again about 12 hours after, when the medication is at its highest levels in your body. You will also have a routine MRI scan before your surgery (which you may already be scheduled for anyway). All samples will be carefully processed and stored so doctors can measure specific chemicals that may help them understand your tumor better. The entire study involvement is brief and fits around your normal surgical care.
AI-generated summary from trial data · Sep 5, 2026 · Not medical advice
Italy
Sponsor
Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta
Collaborators
University of Milan, Università degli Studi del Piemonte Orientale Amedeo Avogadro
Enrollment target
~30 participants
Started
May 2024
Primary completion
December 2026
Age range
18 Years and older
Last updated on clinicaltrials.gov in August 2026.