Testing a new injection to lower cholesterol in adults

Plain-English translation of NCT07421297 on ClinicalTrials.gov ↗ · Source last updated April 2026 · Translation generated August 2026 · How we translate trials

Phase 3 — Testing in thousands of people, comparing the treatment against what doctors currently use. This is the last big step before approval.

What is this trial?

This study is testing a medication called SYH2053, given as an injection under the skin, to see if it can effectively and safely lower cholesterol in adults who have high cholesterol that isn't caused by inherited genetic factors. About 760 people will participate, and half will receive the real medication while half will receive a placebo (a dummy injection) to compare results.

Many people have high cholesterol that increases their risk of heart disease, and doctors need more treatment options—especially for patients who don't respond well enough to current medications or need additional help managing their cholesterol levels.

Do you qualify?

You likely qualify if…

you are 18 years old or older
you have high cholesterol or mixed lipid problems that haven't reached target levels with current treatment
your triglyceride (fat) levels are below 500 mg/dL
you haven't taken most cholesterol-lowering medications in the past 3 months
you are able to communicate clearly with the study team and follow the study plan

You likely don't qualify if…

you have familial hypercholesterolemia (inherited high cholesterol) or other rare diseases that cause high cholesterol
you have a history of heart attack, stroke, or significant heart or blood vessel disease
you are currently taking most cholesterol-lowering medications or have recently taken newer cholesterol drugs
you have severe kidney disease, severe liver disease, or uncontrolled high blood pressure
you have had cancer in the past 5 years or an active cancer diagnosis being investigated

What participation looks like

You will be randomly assigned to receive either the new injection or a placebo, and you'll give it to yourself under the skin according to the study schedule. You'll have regular clinic visits for blood tests to check your cholesterol levels and make sure the medication is safe and working. The study team will track how well the treatment works and watch for any side effects throughout your participation.

AI-generated summary from trial data · Aug 20, 2026 · Not medical advice

Trial locations(2 sites)

China

Affiliation: Peking University Third Hospital, Beijing, Beijing Municipality