Plain-English translation of NCT07423273 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
This trial is testing hyperbaric oxygen therapy (HBOT) — a treatment where you breathe pure oxygen inside a special pressurized chamber — to see if it can help reduce depression that occurs after a stroke. About one in three stroke survivors develops this type of depression, which can slow recovery and increase the risk of another stroke. Researchers believe that increasing oxygen to the brain may help it heal and repair itself.
Depression after stroke is common and can get in the way of recovery, but current medications don't always work well for everyone. Early research suggests this treatment might help wake up damaged areas of the brain and reduce depressive symptoms, even years after a stroke.
You likely qualify if…
You likely don't qualify if…
You would receive 60 sessions of treatment over three months, visiting five times per week. Each session lasts 90 minutes, during which you sit in a pressurized chamber and breathe oxygen (or air, if you're in the comparison group). After the three months of treatment, you'll have a three-month follow-up period with check-ins. You'll also need brain imaging scans and depression assessments to help researchers measure whether the treatment is working.
AI-generated summary from trial data · Jun 22, 2026 · Not medical advice
Israel
Sponsor
Assaf-Harofeh Medical Center
Enrollment target
~142 participants
Started
November 2023
Primary completion
December 2030
Age range
50 Years – 85 Years
Last updated on clinicaltrials.gov in April 2026.
Reach out to the team running this trial. Response times vary — some teams are faster than others.
Central contact
Shai a Efrati, MD
Asaf-Harofhe MC
Tell us you're interested and we'll help connect you with the research team. We'll walk you through what to expect first — no email needed to get started.