Recruiting

Testing a modified virus treatment injected directly into brain tumors

Plain-English translation of NCT07424092 on ClinicalTrials.gov ↗ · Source last updated May 2026 · Translation generated June 2026 · How we translate trials

Phase 2 — Testing in a bigger group (up to a few hundred people) to see if the treatment actually works and is still safe.

What is this trial?

This trial is testing , a genetically modified virus designed to attack and destroy tumor cells while activating your body's immune system to fight the cancer. The virus is injected directly into the brain tumor during a biopsy procedure. Research in animals and early human trials suggests this approach is safe and may help children and young adults with high-grade brain tumors that have returned or are no longer responding to standard treatments.

High-grade brain tumors in children and young adults have very poor outcomes, and when these tumors come back after initial treatment, there are currently no cures available. This medication represents a new approach that could improve survival and quality of life for patients who have limited options.

Do you qualify?

You likely qualify if…

you are between 1 and 25 years old
you have been diagnosed with a recurrent or treatment-resistant high-grade brain tumor (such as a glioma, medulloblastoma, or ependymoma)
your tumor cannot be completely removed by surgery, or surgery is not safe for you
you are expected to live at least 16 weeks from the time you join the study
your tumor is large enough to see on imaging and in a location where it can be safely biopsied and injected
you are healthy enough (based on performance status scores) to tolerate the procedure

You likely don't qualify if…

you have received chemotherapy or immunotherapy in the 4 weeks before enrollment
you have had radiation therapy to the brain or spinal cord in the 6 weeks before enrollment
your blood counts, kidney function, or liver function are not within safe ranges
you are pregnant or unwilling to use birth control during and for several months after treatment
your tumor is located in the spine or other locations deemed unsafe for this procedure

What participation looks like

You will undergo a stereotactic brain biopsy (a minimally invasive procedure using imaging guidance to reach the tumor safely), and during that same procedure, the modified virus treatment will be injected directly into the tumor. You will then be monitored closely with imaging scans and blood tests to see how your tumor responds and to track any side effects. Follow-up visits will assess your recovery and how well the treatment is working.

AI-generated summary from trial data · Jun 4, 2026 · Not medical advice

Trial locations(2 sites)

Netherlands

Princess Máxima Centrum, Utrecht

Spain

Cancer Center Clínica Universidad de Navarra, Pamplona, Navarre