Plain-English translation of NCT07425769 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
This study is testing whether remote (video-based) exercise classes and caregiver training can help adults with Down syndrome maintain their physical fitness and daily functioning. You and your caregiver would participate together in 12 weeks of guided exercise sessions over video call, while your caregiver also receives training on managing dementia-related changes that can occur in adults with Down syndrome as they age.
Adults with Down syndrome are at higher risk for early cognitive decline and Alzheimer's-related changes as they get older. This trial aims to see if staying physically active and having well-trained caregivers can help slow or prevent these changes and keep people healthier for longer.
You likely qualify if…
You likely don't qualify if…
Over 12 weeks, you would join three 30-minute exercise classes per week over video call with a trained instructor guiding you through activities designed to improve strength, balance, flexibility, and endurance. Your caregiver can join the exercise sessions if they wish, and they would also attend a separate weekly 40-minute video training session focused on caregiving skills and support. Research staff will visit your home at the start and end of the study to assess your fitness, set up monitoring equipment, and collect some saliva samples from your caregiver.
AI-generated summary from trial data · Jun 7, 2026 · Not medical advice
United States
Sponsor
University of Kansas Medical Center
Collaborators
National Center for Advancing Translational Sciences (NCATS)
Enrollment target
~40 participants
Started
March 2026
Primary completion
July 2026
This trial's estimated completion date has passed — the record may not be fully up to date.
Last updated on clinicaltrials.gov in May 2026.
Reach out to the team running this trial. Response times vary — some teams are faster than others.
Central contact
Amy Bodde, PhD
University of Kansas Medical Center
Tell us you're interested and we'll help connect you with the research team. We'll walk you through what to expect first — no email needed to get started.