Recruiting

Testing a plant-based cream for psoriasis skin patches

Plain-English translation of NCT07426120 on ClinicalTrials.gov ↗ · Source last updated February 2026 · Translation generated June 2026 · How we translate trials

Phase 3 — Testing in thousands of people, comparing the treatment against what doctors currently use. This is the last big step before approval.

What is this trial?

This trial is testing a botanical total coumarin cream (TC Cream) — a plant-based topical treatment — to see if it can safely and effectively reduce psoriasis patches on the skin. About 300 people will be randomly assigned to either use the active medication or a look-alike cream with no active ingredient, applied twice daily for 8 weeks. Researchers will measure skin improvement and track any side effects to understand whether this treatment works and is safe.

Many people with psoriasis need new treatment options that are easy to use and have fewer side effects than existing therapies. This study aims to test whether this plant-based medication could become a safe and effective topical choice for managing psoriasis.

Do you qualify?

You likely qualify if…

you are between 18 and 70 years old
you have been diagnosed with stable psoriasis vulgaris with at least two areas suitable for evaluation
your psoriasis covers between 1% and 20% of your body surface
you are willing to use birth control if you are a woman of childbearing age
you have not had recent psoriasis treatments — specifically, no topical or light therapy in the past 4 weeks, and no systemic medications or biologics in the past 3 months

You likely don't qualify if…

you are pregnant, trying to become pregnant, or breastfeeding
you have a history of severe allergic reactions or extreme light sensitivity
you have serious heart, brain, liver, kidney, or blood disorders, or psychiatric conditions
you have a history of photosensitive diseases like porphyria or xeroderma pigmentosa
you are allergic to coumarin compounds or similar plant-derived ingredients

What participation looks like

You will apply your assigned cream (either the active treatment or a placebo) to affected skin areas twice daily — once in the morning and once in the evening — for 8 weeks. You'll visit the clinic every 2 weeks for checkups where doctors will examine your skin, measure how much your psoriasis has improved, and ask about any symptoms or side effects you may be experiencing. The study takes about 2 months from start to finish, with regular monitoring to ensure the treatment is working and safe.

AI-generated summary from trial data · Jun 2, 2026 · Not medical advice

Testing a plant-based cream for psoriasis skin patches

What is this trial?

Do you qualify?

What participation looks like

Trial locations