Recruiting

Testing sound wave technology to treat liver tumors

Plain-English translation of NCT07428356 on ClinicalTrials.gov ↗ · Source last updated February 2026 · Translation generated June 2026 · How we translate trials

This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.

What is this trial?

This study is testing a treatment called histotripsy, which uses focused sound waves to destroy liver tumors without cutting into the body. The procedure is performed under general anesthesia, and researchers will track how safe it is and how well it works for people with liver cancer or cancer that has spread to the liver.

Many patients with liver tumors cannot have surgery or are not helped by existing treatments. This new treatment offers another option that may be less invasive than traditional surgery while still being effective at destroying tumors.

Do you qualify?

You likely qualify if…

you are at least 21 years old
you have been diagnosed with cancer in the liver (either primary liver cancer or cancer spread from elsewhere) that cannot be surgically removed or that you have chosen not to have surgery for
you have no more than 3 liver tumors, each measuring 3 centimeters or smaller
your tumors can be seen and targeted clearly on ultrasound
your liver and blood counts are in acceptable condition based on recent lab work
you are well enough to receive general anesthesia as confirmed by a pre-anesthesia evaluation

You likely don't qualify if…

you have cancer that has spread outside the liver in a way that needs immediate treatment
your tumors are directly wrapped around or involved with major blood vessels in the liver
your tumors are located very close to your stomach or colon, where the procedure could cause damage
you have severe heart disease, uncontrolled high blood pressure, active infection, or severe lung disease
you are pregnant or breastfeeding

What participation looks like

You will have baseline imaging scans and blood tests, then receive the histotripsy procedure under general anesthesia at one of the participating hospitals in Asia. After the procedure, you will return for follow-up visits at scheduled intervals where doctors will check your recovery with imaging scans, blood tests, and clinical assessments to see how well the treatment worked and monitor for any side effects.

AI-generated summary from trial data · Jun 7, 2026 · Not medical advice

Trial locations(3 sites)

Singapore

National University Hospital, Singapore

National Cancer Centre Singapore, Singapore

Singapore General Hospital, Singapore