Recruiting

Exercise and diet program to reduce heart rhythm problems and weight

Plain-English translation of NCT07430007 on ClinicalTrials.gov ↗ · Source last updated February 2026 · Translation generated June 2026 · How we translate trials

This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.

What is this trial?

MOVE-AF is testing whether a tailored 12-month lifestyle program—combining personalized exercise training and dietary counseling—can reduce how often atrial fibrillation episodes happen and decrease unhealthy fat deposits around the heart. The study enrolls people who are overweight or obese and have been diagnosed with atrial fibrillation (an irregular heartbeat). Half of participants will receive this new lifestyle program along with their usual care, while the other half will receive usual care alone.

Obesity is a major driver of atrial fibrillation, but we don't have strong long-term evidence showing whether combining exercise and diet changes—monitored carefully with heart imaging—can truly reduce symptom burden and improve outcomes.

Do you qualify?

You likely qualify if…

you are between 18 and 75 years old
you have a body mass index of 27 kg/m² or higher (overweight or obese)
you have been diagnosed with atrial fibrillation (either paroxysmal or persistent type)
you are physically able to participate in exercise training and follow the study procedures
you have access to a smartphone or device that can track your heart rhythm

You likely don't qualify if…

you have permanent atrial fibrillation (rather than paroxysmal or persistent)
you have had unstable chest pain or a heart attack in the past 3 months
you have severe heart failure or severely weakened heart function
you have a medical condition (such as severe lung disease, active cancer, or recent joint surgery) that makes exercise unsafe or infeasible
you are pregnant, breastfeeding, or already enrolled in another weight loss or lifestyle intervention study

What participation looks like

If you are assigned to the lifestyle program group, you will receive personalized guidance on aerobic exercise (like walking or cycling) and muscle-strengthening activities, plus dietary counseling—all tailored to your needs—for 12 months, alongside your regular heart care. All participants will wear a continuous heart rhythm monitor to track atrial fibrillation episodes, have heart imaging scans (MRI) to measure fat around the heart, and answer questionnaires about symptoms. The study lasts one year and involves regular visits with the research team to monitor your progress.

AI-generated summary from trial data · Jun 14, 2026 · Not medical advice

Trial locations(4 sites)

Finland

Hospital Nova of Central Finland, Jyväskylä, Central Finland

University of Eastern Finland, Kuopio, Eastern Finland

Kuopio University Hospital, Kuopio, Northern Savonia

Tampere University Hospital, Tampere