Recruiting

Testing a new medication to protect the brain after stroke treatment

Plain-English translation of NCT07430917 on ClinicalTrials.gov ↗ · Source last updated August 2026 · Translation generated August 2026 · How we translate trials

Phase 2 — Testing in a bigger group (up to a few hundred people) to see if the treatment actually works and is still safe.

What is this trial?

This study is testing whether a medication called J147 can help protect your brain and improve your recovery after you've had an acute ischemic stroke (a stroke caused by a blood clot) and received emergency mechanical thrombectomy—a procedure to remove the clot. The medication will be given as a single injection into your vein right after your thrombectomy procedure.

When someone has a stroke, the brain needs quick treatment to restore blood flow, but brain injury can still occur during and after that treatment. Researchers believe this medication might help reduce that injury and improve recovery by protecting brain tissue.

Do you qualify?

You likely qualify if…

you have experienced a new stroke with a confirmed large blood vessel blockage in the brain
your stroke symptoms are moderate in severity (measured by standard stroke severity scales)
you were able to function independently before your stroke
you can be treated within 24 hours of when your stroke started
you are eligible to receive the mechanical thrombectomy procedure without other clot-busting medications
you successfully had your blood flow restored through mechanical thrombectomy

You likely don't qualify if…

you received intravenous thrombolytic therapy (clot-busting medication given through the vein) before enrollment
you are a woman of childbearing age who cannot commit to using effective birth control during and for 30 days after the study
you are pregnant or planning to become pregnant during the study period
you have significant disability or dependence on others for daily activities before your stroke

What participation looks like

If you qualify and enroll, you will first receive the standard emergency mechanical thrombectomy procedure to remove the blood clot from your brain. Once the procedure is successful and blood flow is restored, you will receive a single injection of either the new medication J147 or a placebo (inactive substance). The study is divided into two phases: in the first phase, some participants will receive different doses of the medication to find the safest and most effective dose; in the second phase, all participants will receive that selected dose or a placebo. You will be monitored with imaging tests and clinical assessments to measure how well the treatment works and whether it is safe.

AI-generated summary from trial data · Aug 27, 2026 · Not medical advice

Trial locations(5 sites)

United States

MemorialCare Long Beach Medical Center, Long Beach, California

Javon Bea Hospital, Rockford, Illinois

Albany Medical Center, Albany, New York

Oregon Health and Science University, Portland, Oregon

Dell Seton Medical Center at the University of Texas at Austin, Austin, Texas