Plain-English translation of NCT07441928 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
This study looks at whether two different smoking-cessation programs can help people with schizophrenia quit or reduce smoking, and how they affect brain activity and psychotic symptoms. Researchers will use brain imaging (called fMRI) to see how the brain responds before, right after, and 6 months after each program. One program uses a method called Acceptance and Commitment Therapy, while the other uses a more traditional counseling approach.
People with schizophrenia smoke at much higher rates than the general population, which harms their physical health. Researchers don't yet know which smoking-cessation approaches work best for this group or how these programs might help reduce psychotic symptoms along with smoking.
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If you smoke, you'll be randomly assigned to try one of two smoking-cessation programs. Both involve regular sessions with counselors or therapists who will help you quit or cut back on smoking. You'll also have brain imaging scans (fMRI) at three points: before the program starts, right after it ends, and 6 months later. The entire study takes about 6 months, with visits spread throughout that time. If you don't smoke, you'll join a comparison group and complete the same brain imaging scans to help researchers understand differences between smokers and non-smokers with schizophrenia.
AI-generated summary from trial data · Jun 11, 2026 · Not medical advice
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