Comparing two ways to give anti-inflammatory medicine before knee replacement surgery

This trial compares two different ways of giving dexamethasone—an anti-inflammatory medicine—to patients having knee replacement surgery. Some patients receive it as an injection, some receive it by mouth, and some don't receive it at all. The study tracks how well each approach helps with pain, nausea, and ability to move around in the days after surgery.

Knee replacement surgery can cause significant pain and swelling, which can slow your recovery and make it harder to start moving and healing. While this medication is already commonly used to reduce inflammation and pain after surgery, doctors aren't sure whether giving it by injection or by mouth works better—or if it even matters. This study aims to answer that question using real-world data from actual patients.