Plain-English translation of NCT07443293 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Phase 2 — Testing in a bigger group (up to a few hundred people) to see if the treatment actually works and is still safe.
This trial is testing whether a 6-month program combining regular exercise, mindfulness meditation, and a brain-healthy diet can help protect against Parkinson's disease progression or symptoms. Researchers are enrolling people aged 40–85 who have either been diagnosed with Parkinson's disease or have a sleep disorder called REM Sleep Behavior Disorder (which often precedes Parkinson's). The study compares people who start the program right away with people who wait 6 months, allowing researchers to measure whether these lifestyle changes make a real difference.
Parkinson's disease has no current treatment that can slow or stop its progression, and it affects movement, thinking, and daily life. Research suggests that exercise, meditation, and healthy eating may protect the brain and reduce inflammation, but this study aims to confirm whether these approaches actually work when combined together.
You will have a baseline assessment including questionnaires and brain imaging. Then you'll either start the 6-month program immediately or join a waitlist group. If you're in the program group, you'll exercise regularly, practice meditation, follow a Mediterranean-style diet, and use a wearable fitness tracker to monitor your activity. If you're in the waitlist group, you'll continue your normal routine for 6 months (while wearing a tracker), then do the same 6-month program afterward. Throughout, you'll complete monthly questionnaires and have final assessments to measure any changes in your symptoms and brain health.
AI-generated summary from trial data · Jun 28, 2026 · Not medical advice
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