Plain-English translation of NCT07443514 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
Researchers want to understand how chemotherapy affects thinking, memory, and concentration in people with diffuse large B-cell lymphoma (a type of blood cancer). Some patients will receive standard chemotherapy alone, while others will also receive additional chemotherapy injected into the spinal fluid. The study will track how the medication affects thinking abilities over time and identify which patients are most at risk for memory or concentration problems.
Cancer treatment can sometimes affect thinking and memory, but doctors don't yet know exactly which patients are most likely to experience these problems or how to predict them. This study hopes to identify early warning signs and better understand which factors (like the type of treatment or certain markers in the spinal fluid) can help predict who might have trouble with thinking or memory after treatment.
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If you have lymphoma, you will complete thinking and memory tests before starting chemotherapy, after your first round of treatment, and again 12 months after starting treatment. If you also receive chemotherapy injected into your spinal fluid, you'll have one additional memory test before your final spinal injection. Healthy relatives will complete similar thinking and memory tests for comparison. The study uses spinal fluid samples that are already being collected for your medical care — no extra procedures are done just for research.
AI-generated summary from trial data · Jun 27, 2026 · Not medical advice
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