Recruiting

Testing a new preventive treatment for severe COVID-19

Plain-English translation of NCT07445971 on ClinicalTrials.gov ↗ · Source last updated September 2026 · Translation generated September 2026 · How we translate trials

Phase 1 — Testing in a small group (usually 20–80 people) to find a safe dose and watch for side effects.

What is this trial?

This is the first human study of , a new medication designed to help prevent severe COVID-19. Researchers will give some participants the medication and others a placebo (inactive treatment) by injection, then monitor everyone closely to see how safe the medication is and how the body responds to it.

COVID-19 can be life-threatening, especially for people with chronic health conditions. This medication is being tested to see if it offers a new way to protect people who are most vulnerable to severe illness.

Do you qualify?

You likely qualify if…

you are between 18 and 64 years old
you are generally healthy, or you have a chronic health condition like asthma, diabetes, heart disease, or kidney disease that puts you at higher risk for severe COVID-19
you are clinically stable and have not been hospitalized in the past year due to your health conditions
you have not received a COVID-19 vaccine or monoclonal antibody treatment before joining the study
if you are a woman who could become pregnant, you have a negative pregnancy test and agree to use reliable birth control during the study

You likely don't qualify if…

you currently have COVID-19 or tested positive for it recently
you have active hepatitis B or C infections
you are pregnant or breastfeeding
you have received a COVID-19 vaccine or monoclonal antibody treatment before the study starts
you are taking immunosuppressant medications or high-dose steroids

What participation looks like

You will receive either the new medication or a placebo as an injection (through an IV, into a muscle, or under the skin). Some participants receive just one injection, while others receive a second injection about 3 months later. Throughout the study, researchers will check your vital signs, do blood tests, and ask about any side effects you experience. The entire study lasts several months.

AI-generated summary from trial data · Sep 16, 2026 · Not medical advice

Trial locations(2 sites)

United States

TrialMed Clinical Research Unit, Las Vegas, Nevada

TrialMed Clinical Research Unit, Austin, Texas