Plain-English translation of NCT07446998 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Phase 2 — Testing in a bigger group (up to a few hundred people) to see if the treatment actually works and is still safe.
This trial is testing whether , a new oral medication taken daily, can help people who are already using semaglutide (a weight-loss injection) lose more weight and maintain better physical strength. About 200 people will participate: half will receive the new medication plus the injection, and half will receive a placebo (dummy pill) plus the injection. The study will last about 16 months to see how well the medication works and whether it is safe.
People using weight-loss medications often lose muscle along with fat, which can make it harder to stay active and mobile—especially as we age. This trial is testing whether adding this new treatment could help preserve or build muscle strength while still achieving weight loss.
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You will come to a study clinic and begin receiving weekly or regular injections of the weight-loss medication on day one. You will also take a daily oral pill—either the new medication or a placebo—for 16 months. During this time, you will have regular clinic visits to measure your weight, test your physical strength and function, and check for any side effects. A final safety check-up will happen about 30 days after your last dose.
AI-generated summary from trial data · Jul 10, 2026 · Not medical advice
United States