Heart plaque changes with a new cholesterol medication

This study is tracking how adding a new medication called evinacumab to standard cholesterol treatments affects the buildup of plaque in heart arteries. Researchers will compare patients who receive evinacumab with patients receiving standard cholesterol treatments alone, using heart imaging scans to see whether the medication helps slow, stop, or even reverse plaque growth over time.

People with a rare inherited condition called homozygous familial hypercholesterolemia have dangerously high cholesterol levels that don't respond well to standard treatments, leading to heart disease at a young age. This study exists to find out whether this new treatment can actually reduce the plaque buildup in their arteries and protect their hearts.