Does a new cholesterol drug slow heart plaque buildup in rare genetic disease?

This study is looking at whether Evinacumab, a newer cholesterol-lowering medication, can slow or stop the buildup of plaque in the heart arteries of people with homozygous familial hypercholesterolemia (a rare genetic condition that causes very high cholesterol levels from birth). Researchers will compare heart CT scans taken before and after patients start taking the medication—or continue without it—to see if this treatment makes a real difference in protecting the heart.

People with this rare genetic cholesterol condition often have dangerously high cholesterol levels even when taking multiple medications, putting them at risk for heart attacks at a young age. This medication works differently than older drugs, so doctors want to confirm that it actually slows the damage to the heart arteries in real-world patients.