Testing a shorter radiation schedule with immunotherapy for advanced rectal cancer

This trial is testing a new approach to treating advanced rectal cancer that hasn't spread beyond the local area. Instead of the standard long course of radiation therapy, participants will receive a much shorter radiation schedule combined with chemotherapy and a medication called Enlonstobart (an immunotherapy drug that helps your immune system fight cancer). The goal is to see if this shorter, faster approach works just as well or even better than the traditional treatment.

Standard rectal cancer treatment requires long weeks of radiation therapy, which can be hard on patients and take a long time. This trial is exploring whether this new immunotherapy medication, combined with a much shorter radiation schedule, could be just as effective but faster and potentially easier to tolerate.