Plain-English translation of NCT07448974 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Phase 3 — Testing in thousands of people, comparing the treatment against what doctors currently use. This is the last big step before approval.
This trial is testing whether cholecalciferol (vitamin D) taken once a week, with doses adjusted based on your blood levels, can help keep blood sugar under better control in people with prediabetes. Research suggests vitamin D may play a role in how your body manages blood sugar, so this study wants to see if reaching a specific vitamin D level in your blood improves your ability to maintain healthy blood sugar levels compared to a placebo (a pill with no active ingredient).
People with prediabetes are at high risk of developing type 2 diabetes, and current treatment options are limited. Scientists believe that vitamin D may help your body control blood sugar better, so this trial will test whether adjusting the medication dose to reach an optimal level actually makes a real difference in preventing diabetes.
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You will be randomly assigned to take either weekly vitamin D or a placebo pill for about 18 months. If you receive the medication, your dose may be adjusted after 3 months based on blood tests. Throughout the study, you will attend scheduled clinic visits, have regular blood tests, wear a small continuous glucose monitor device to track your blood sugar throughout the day and night, and receive periodic phone check-ins from the research team to monitor your health and medication use.
AI-generated summary from trial data · Aug 27, 2026 · Not medical advice
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