Brain Stimulation to Improve Language in Memory Loss Diseases

Plain-English translation of NCT07449117 on ClinicalTrials.gov ↗ · Source last updated March 2026 · Translation generated June 2026 · How we translate trials

This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.

What is this trial?

This study investigates temporal interference stimulation (TIS), a non-invasive technique that uses electrical currents to stimulate deep brain areas involved in language and communication. Researchers want to see if a single 20-minute session of this stimulation can immediately improve how your brain processes language and how you understand sentences. The study will test this in people with early-stage cognitive decline from neurodegenerative diseases.

Many people with conditions like Parkinson's disease and Lewy body disease experience trouble with language and understanding sentences as their disease progresses. This trial explores whether this new brain stimulation technique could help protect or improve these abilities—potentially offering a way to reduce communication problems that often develop with these conditions.

Do you qualify?

You likely qualify if…

you have been diagnosed with mild cognitive impairment, either on its own or as part of Parkinson's disease or Lewy body disease
you are able to undergo an MRI scan and brain imaging
you are willing to complete language and thinking tasks during the study

You likely don't qualify if…

you have a severe psychiatric disorder
you have other neurological diseases that affect your brain or nervous system
you have a history of severe head trauma
you have a pacemaker or other metal implants in your body that are not compatible with MRI machines
you have an uncontrolled medical condition or active cancer

What participation looks like

You will attend a single study visit where you'll receive two 20-minute brain stimulation sessions—one real and one placebo (sham)—separated by a break. During each session, you'll perform language tasks while the stimulation is applied to help researchers measure its effects. Before and after the stimulation, you'll have brain imaging scans to see how the treatment affects your brain activity and connectivity.

AI-generated summary from trial data · Jun 25, 2026 · Not medical advice

Trial locations(1 site)

Czechia

CEITEC MU (Central European Institute of Technology, Masaryk University), Brno, South Moravian