Recruiting

Nerve Block Pain Relief During Hip Replacement Surgery

Plain-English translation of NCT07449403 on ClinicalTrials.gov ↗ · Source last updated July 2026 · Translation generated July 2026 · How we translate trials

This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.

What is this trial?

This trial is testing whether a nerve block technique called a pericapsular nerve group (PENG) block can reduce the body's inflammatory response after hip replacement surgery. The study compares patients who receive the actual medication (ropivacaine) with patients who receive a placebo injection, measuring markers of inflammation in the blood to see if this treatment helps with pain control and recovery.

Surgery triggers a natural inflammatory response in your body that can affect healing and increase the risk of complications. This trial is investigating whether using this nerve block technique during surgery can calm that inflammatory response more effectively than traditional approaches, potentially leading to better recovery and fewer complications.

Do you qualify?

You likely qualify if…

you are between 65 and 100 years old
you have been diagnosed with hip arthritis and are scheduled for hip replacement surgery
you are in generally good health or have well-controlled medical conditions (ASA classification I–III)
you will be having your surgery under spinal anesthesia

You likely don't qualify if…

you have a bleeding disorder or history of abnormal bleeding
you are currently taking anticoagulant medications (blood thinners)
you have chronic pain conditions that existed before this surgery
you have dementia or are unable to accurately report your pain level
you have an active infection in the area where the nerve block would be performed

What participation looks like

You would come in for your scheduled hip replacement surgery and receive either the active nerve block medication or a placebo injection as part of your anesthesia. Before surgery and at 12, 24, and 48 hours after surgery, researchers will take blood samples to measure inflammation markers. Your participation would last approximately 2 days of hospital monitoring and follow-up assessments.

AI-generated summary from trial data · Jul 11, 2026 · Not medical advice

Trial locations(1 site)

Poland

Poznan University of Medical Sciences, Poznan