Plain-English translation of NCT07450547 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Phase 2 — Testing in a bigger group (up to a few hundred people) to see if the treatment actually works and is still safe.
This trial is testing a new medication called ANG003, which is a pancreatic enzyme replacement therapy designed to help people with cystic fibrosis whose pancreas doesn't produce enough digestive enzymes. Researchers want to see if this medication works just as well as , the current standard enzyme treatment that many CF patients already use. The study will compare how well the new medication helps your body digest food compared to .
People with cystic fibrosis often struggle with pancreatic insufficiency, meaning their pancreas doesn't make enough enzymes to properly digest food. This can lead to poor nutrition and digestive problems. Researchers are developing this medication as a potential new option that might work just as well as—or better than—current treatments.
You likely qualify if…
You likely don't qualify if…
You would start by taking (the standard enzyme medication) for 14 days, then have a stool test to measure how well you're digesting food. If you qualify, you would then be randomly assigned to take either the new ANG003 medication at one of two dose levels, continue with , or take no enzyme medication for 21 days. At the end of that period, you would have another stool test to see how well the treatment worked. The study aims to compare how effectively the new medication helps your digestion compared to the current standard treatment.
AI-generated summary from trial data · Jul 18, 2026 · Not medical advice
United States