Comparing two pain relief medications after heart bypass surgery

Plain-English translation of NCT07451522 on ClinicalTrials.gov ↗ · Source last updated March 2026 · Translation generated July 2026 · How we translate trials

This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.

What is this trial?

This study is testing whether a newer medication called can relieve pain as well as morphine in the hours right after heart bypass surgery. Researchers will compare how well each medication reduces pain and monitor how your body responds to each one.

After heart bypass surgery, patients experience significant pain that needs to be treated quickly and effectively. This trial is exploring whether this medication could be an alternative to morphine, potentially offering better pain control or fewer side effects for heart surgery patients.

Do you qualify?

You likely qualify if…

you are between 18 and 75 years old
you are undergoing coronary artery bypass grafting (CABG) heart surgery
you are in good overall health, with an ASA score of 2 or lower
your body mass index (weight and height ratio) is between 18.5 and 35 kg/m²
you have not taken pain-affecting medications before surgery
you do not have an active infection at the time of enrollment

You likely don't qualify if…

you are pregnant or breastfeeding
you are allergic to morphine, opioid medications, or any ingredients in tafalgin
you have severe liver disease (cirrhosis, Child-Pugh class C) or acute kidney failure requiring dialysis
you are currently taking certain psychiatric medications (MAOIs) or have stopped them less than 14 days ago
you have severe lung disease (advanced COPD or active asthma) or you regularly use alcohol, sedatives, or other central nervous system depressing drugs

What participation looks like

You will have heart bypass surgery as planned. In the first 24 hours after your surgery, if your pain rating exceeds a certain level, you will receive a single injection of either morphine or the new medication (tafalgin), depending on which group you're randomly assigned to. Researchers will measure your pain relief using a simple pain scale, and they will monitor your heart function and blood oxygen levels to see how your body responds.

AI-generated summary from trial data · Jul 16, 2026 · Not medical advice

Comparing two pain relief medications after heart bypass surgery

What is this trial?

Do you qualify?

What participation looks like

Trial locations