Plain-English translation of NCT07454720 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Phase 3 — Testing in thousands of people, comparing the treatment against what doctors currently use. This is the last big step before approval.
This trial is testing whether combining two medications called Adebrelimab and SHR-8068 with standard radiation and can work better than radiation and alone for treating locally advanced rectal cancer. Participants will receive this combination treatment before surgery to try to shrink the cancer and improve survival. The study will also check how safe these medications are when used together with radiation and .
Rectal cancer that has spread locally but can still be surgically removed is serious and requires aggressive treatment. Researchers want to see if adding these new medications to standard treatment can help more patients recover fully and reduce the chance of cancer returning.
You likely qualify if…
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You would receive radiation therapy combined with and the new medications before surgery to remove your rectal cancer. The treatment would take place over several weeks at a hospital or cancer center, with regular visits to monitor your health and side effects. After completing the medication and radiation treatment, you would have surgery to remove the cancer, followed by continued follow-up care to watch for any recurrence.
AI-generated summary from trial data · Sep 3, 2026 · Not medical advice
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