Recruiting

Testing a new treatment for immune system diseases affecting joints and skin

Plain-English translation of NCT07455578 on ClinicalTrials.gov ↗ · Source last updated June 2026 · Translation generated June 2026 · How we translate trials

Phase 1 — Testing in a small group (usually 20–80 people) to find a safe dose and watch for side effects.

What is this trial?

This study is testing a new medication called to treat several autoimmune and immune-related diseases, including rheumatoid arthritis, psoriatic arthritis, psoriasis, lupus, and eczema. Researchers want to understand how the medication works in your body, how safe it is, and whether it helps reduce symptoms. This is an early-stage trial, meaning has not yet been widely used in patients.

Current treatments for autoimmune diseases don't work well enough for everyone, and some patients can't tolerate existing options. This trial is exploring whether this new medication could offer another choice for people whose diseases are not adequately controlled.

Do you qualify?

You likely qualify if…

you are between 18 and 75 years old
you have a confirmed diagnosis of rheumatoid arthritis, psoriatic arthritis, psoriasis, cutaneous lupus, or atopic dermatitis that has been present for at least several months
your disease is currently active and causing noticeable symptoms (such as swollen joints, skin lesions, or inflammation)
you have already tried at least one standard treatment for your condition and either it didn't work well enough, stopped working, or you couldn't tolerate it
you are willing to use effective contraception during the study if you are capable of pregnancy
you have a body mass index between 18.0 and 40.0 and weigh at least 45 kg

You likely don't qualify if…

you have recently received certain immune-suppressing therapies, such as cell therapy, B-cell therapies, or checkpoint inhibitors
you are currently taking or recently took medications like azathioprine, cyclosporine, or tacrolimus without waiting the required time
you have a current infection or history of serious infections
you have any personal history of cancer
you have been treated with three or more biologic or targeted synthetic drugs for your condition without adequate response

What participation looks like

You would receive injections of the medication under your skin at a medical facility over the course of the study. The trial involves visits where doctors will examine you, take blood samples to check how your body is responding, and ask about any side effects or changes in your symptoms. The study is designed to involve about 24 participants total across multiple centers, and your participation would help researchers understand whether this new treatment is safe and might help people with your condition.

AI-generated summary from trial data · Jun 3, 2026 · Not medical advice

Trial locations(2 sites)

Australia

Novatrials, Charlestown, New South Wales

University of the Sunshine Coast Clinical Trials, Birtinya, Birtinya, Queensland