Testing new medications with radiation therapy for advanced esophageal cancer

Plain-English translation of NCT07457528 on ClinicalTrials.gov ↗ · Source last updated March 2026 · Translation generated June 2026 · How we translate trials

Phase 2 — Testing in a bigger group (up to a few hundred people) to see if the treatment actually works and is still safe.

What is this trial?

This trial is testing whether two new medications called serplulimab and , when combined with standard radiation and , can help treat advanced esophageal squamous cell carcinoma more effectively. The study will enroll 46 patients with this type of cancer and measure how well the combined treatment works and whether it is safe. After the medication and radiation treatment is complete, participants will have surgery to remove the cancer.

Advanced esophageal cancer is a serious disease, and doctors want to improve treatment outcomes by adding newer medications that may help the body's immune system fight the cancer more effectively alongside traditional radiation and .

Do you qualify?

You likely qualify if…

you are between 18 and 75 years old
you have been diagnosed with locally advanced esophageal squamous cell carcinoma that can be surgically removed
you have not received any prior treatment (surgery, radiation, or chemotherapy) for your esophageal cancer
your blood counts, kidney function, liver function, heart function, and lung function are adequate based on recent lab tests and imaging
you are willing to use contraception during the study and for 6 months afterward

You likely don't qualify if…

you have received certain EGFR-blocking medications in the past six months
you have serious heart problems, uncontrolled high blood pressure, kidney failure, severe diabetes, or other major health conditions that your doctor deems unsafe for this trial
you have active cancer elsewhere in your body or a history of other cancers (except skin or cervical cancer treated years ago)
you have an active infection or an active infectious disease
your imaging shows the tumor has invaded major blood vessels or you have signs of esophageal fistula or perforation

What participation looks like

You will receive radiation therapy (delivered over several weeks) along with and the two new medications given by infusion. About 6 to 8 weeks after finishing this combined treatment, if your doctor determines it is safe, you will have surgery to remove the cancer. The trial involves regular visits to the hospital for treatment and monitoring, lab tests, and imaging scans to check how well the treatment is working and to watch for any side effects.

AI-generated summary from trial data · Jun 19, 2026 · Not medical advice

Testing new medications with radiation therapy for advanced esophageal cancer

What is this trial?

Do you qualify?

What participation looks like

Trial locations