Plain-English translation of NCT07462143 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Phase 3 — Testing in thousands of people, comparing the treatment against what doctors currently use. This is the last big step before approval.
This trial is testing a new medication called RC148 combined with standard chemotherapy drugs to treat advanced colorectal cancer that has spread or cannot be surgically removed. Researchers want to see if this new treatment combination works better than the current standard treatment (bevacizumab plus chemotherapy). The study will first test whether the medication is effective and safe, then compare it directly to the standard treatment.
Current treatments for advanced colorectal cancer help many patients, but doctors are always looking for better options that might work more effectively or cause fewer side effects. This trial exists to see if this new medication could offer patients another promising choice.
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If you join this trial, you will receive the new medication RC148 along with standard chemotherapy drugs (given as a combination called CAPEOX). You will visit the research clinic regularly for doctor visits, blood tests, and imaging scans to check how well the treatment is working and to monitor for any side effects. The study will compare how well this new combination works compared to the standard treatment that patients typically receive.
AI-generated summary from trial data · Jun 18, 2026 · Not medical advice
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