Plain-English translation of NCT07465276 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Phase 2 — Testing in a bigger group (up to a few hundred people) to see if the treatment actually works and is still safe.
This trial is testing whether , an experimental medication, works better when combined with (an immunotherapy that's already approved for this type of cancer) in people with advanced head and neck cancer before they have surgery. The idea is to shrink or treat the cancer with medication first, then remove what remains surgically. The trial will enroll about 32 people to see if this combination is safe and effective.
Right now, the standard approach for advanced head and neck cancer often involves surgery, chemotherapy, and radiation. Researchers want to test whether using this medication combination before surgery might improve outcomes or reduce the need for other tough treatments afterward.
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You would receive two cycles of medication over about six weeks: the experimental medication given multiple times per cycle, plus on day one of each cycle. During this time, you'll have blood tests, imaging scans (CT, MRI, or PET), and a tumor biopsy. After completing the two cycles, you would have surgery to remove any remaining cancer. You'll then be followed up for about two years to see how well the treatment worked and monitor your health.
AI-generated summary from trial data · Jun 4, 2026 · Not medical advice
United States