Study of chemotherapy and surgery combinations for rectal cancer with liver spread

This is a research study that follows real-world patients with rectal cancer that has spread to the liver. All participants receive chemotherapy called FOLFIRINOX before surgery. Researchers want to understand which combination of treatment strategies — such as operating on both areas at once, or removing one tumor site first — gives patients the best chance of complete recovery.

When rectal cancer spreads to the liver, doctors must decide the best order and approach for surgery. This study exists to learn which treatment strategies work best in real-world practice and which patients benefit most from different approaches, so future patients can receive the most effective care.