Plain-English translation of NCT07479147 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
This research study is examining the best way to prevent future strokes in older adults (aged 60 and above) who have a small opening between the chambers of their heart, called a patent foramen ovale or PFO. Researchers want to compare two approaches: taking blood-thinning (like direct oral anticoagulants) or undergoing a minimally invasive procedure to close the opening. The study will look at which approach works better at preventing another stroke and gather real-world information from patients' medical records and outcomes.
Most stroke patients worldwide are now older than 60, yet previous research on PFO treatment has focused mainly on younger people. This study exists because doctors need better evidence to know which treatment— or closure—is safest and most effective for older adults, and how to identify which older patients benefit most from each approach.
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If you join this study, you will be assigned to receive either blood-thinning or a procedure to close your heart opening (based on what your doctor recommends and your age group). Your medical records will be reviewed, and you will be followed for several years to track whether you have another stroke and how well your treatment is working. The study combines data from patients treated in the past with new patients enrolling from 2025 onward, so your involvement may include regular clinic visits and sharing your medical information with the research team.
AI-generated summary from trial data · Jun 16, 2026 · Not medical advice
Taiwan